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Article

Single-virion sequencing of lamivudine-treated HBV populations reveal population evolution dynamics and demographic history.

BMC genomics - 27 Oct 2017

Zhu Yuan O, Aw Pauline P K, de Sessions Paola Florez, Hong Shuzhen, See Lee Xian, Hong Lewis Z, Wilm Andreas, Li Chen Hao, Hue Stephane, Lim Seng Gee, Nagarajan Niranjan, Burkholder William F, Hibberd Martin

Abstract excerpt

BACKGROUND: Viral populations are complex, dynamic, and fast evolving. The evolution of groups of closely related viruses in a competitive environment is termed quasispecies. To fully understand the role that quasispecies play in viral evolution, characterizing the trajectories of viral genotypes in an evolving population is the key. In particular, long-range haplotype information for thousands of individual...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29078745
DOI: 10.1186/s12864-017-4217-1
PMCID: PMC5660452

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