Single-Cell Hepatitis B Sequencing Reveals Distinct Viral Infection Events Consistent With Superinfection.

doi:10.1093/infdis/jiag181

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Article

Single-Cell Hepatitis B Sequencing Reveals Distinct Viral Infection Events Consistent With Superinfection.

The Journal of infectious diseases - 2 Sept 2026

Mani Monika, Clipman Steven J, Bailey Justin R, Sterling Richard K, Sulkowski Mark S, Anderson Mark, Olivo Ana, Belluccini Giulia, Cloherty Gavin, Ribeiro Ruy M, Thio Chloe L, Balagopal Ashwin

Abstract excerpt

BACKGROUND: The high error rate of the hepatitis B virus (HBV) polymerase leads to a genetically diverse quasispecies in individuals with chronic hepatitis B. Data regarding the propagation of these variants in individual hepatocytes may provide insight into viral replication and diversity of covalently closed circular DNA (cccDNA), which is the template for HBV replication. METHODS: We developed sequencing...

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Topics

Humans
Hepatitis B virus
Hepatocytes
Superinfection
Hepatitis B, Chronic
DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Haplotypes

Genotype

Genetic Variation

Virus Replication

Sequence Analysis, DNA

Male

Quasispecies

DNA, Circular

HIV Infections

Drug Resistance, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 41856168
DOI: 10.1093/infdis/jiag181
PMCID: PMC13537158

Provenance

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