Article
Characterization of Hepatitis C Virus (HCV) Envelope Diversification from Acute to Chronic Infection within a Sexually Transmitted HCV Cluster by Using Single-Molecule, Real-Time Sequencing.
Journal of virology - 15 Mar 2017
Ho Cynthia K Y, Raghwani Jayna, Koekkoek Sylvie, Liang Richard H, Van der Meer Jan T M, Van Der Valk Marc, De Jong Menno, Pybus Oliver G, Schinkel Janke, Molenkamp Richard
Abstract excerpt
In contrast to other available next-generation sequencing platforms, PacBio single-molecule, real-time (SMRT) sequencing has the advantage of generating long reads albeit with a relatively higher error rate in unprocessed data. Using this platform, we longitudinally sampled and sequenced the hepatitis C virus (HCV) envelope genome region (1,680 nucleotides [nt]) from individuals belonging to a cluster of sexually...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.