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Article

Hepatitis B virus resistance substitutions: long-term analysis by next-generation sequencing.

Archives of virology - 1 Oct 2016

Jones Leandro R, Sede Mariano, Manrique Julieta M, Quarleri Jorge

Abstract excerpt

HBV phylogenetics and resistance-associated mutations (RAMs) were surveyed by next-generation sequencing of 21 longitudinal samples from seven patients entering antiviral therapy. The virus populations were dominated by a few abundant lineages that coexisted with substantial numbers of low-frequency variants. A few low-frequency RAMs were observed before treatment, but new ones emerged, and their frequencies...

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Share to Amino Acid Substitution
Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27447462
DOI: 10.1007/s00705-016-2959-8

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