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P63 in health and cancer

1 Jan 2015

Abstract excerpt

TP63 is the most ancient member of the p53 gene family. The p53 family comprises three transcription factors (p53/p63/p73). They share a high degree of homology and similar domain structure. Yet, they can exist as truncated isoforms. Alternative promoters and splicing sites lead to the generation of several molecules. P53/p63/p73 are important to maintain cell homeostasis. P63 and p73 regulate many p53 target...

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PMID: 26374530
DOI: 10.1387/ijdb.150045sg

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