Article
Emerging Roles of p53 Family Members in Glucose Metabolism.
International journal of molecular sciences - 8 Mar 2018
Itahana Yoko, Itahana Koji
Abstract excerpt
Glucose is the key source for most organisms to provide energy, as well as the key source for metabolites to generate building blocks in cells. The deregulation of glucose homeostasis occurs in various diseases, including the enhanced aerobic glycolysis that is observed in cancers, and insulin resistance in diabetes. Although p53 is thought to suppress tumorigenesis primarily by inducing cell cycle arrest,...
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