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Article

TP53 family members and human cancers.

Human mutation - 1 Mar 2003

Bénard Jean, Douc-Rasy Setha, Ahomadegbe Jean-Charles

Abstract excerpt

Based on gene sequence homologies, a p53 (TP53) gene family become apparent with the addition of the most recently identified p63 (TP73L; formerly TP63) and p73 (TP73) genes to the already known p53. The p53 gene encodes for a unique protein eliciting well-known tumor suppressor gene (TSG) properties that mediate cellular response to DNA damage, e.g., cell cycle arrest or apoptosis. In contrast, both homologues...

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Identifiers

PMID: 12619104
DOI: 10.1002/humu.10172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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