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Mechanisms of Functional Pleiotropy of p73 in Cancer and Beyond

28 Sept 2021

Abstract excerpt

The transcription factor p73 is a structural and functional homolog of TP53, the most famous and frequently mutated tumor-suppressor gene. The TP73 gene can synthesize an overwhelming number of isoforms via splicing events in 5' and 3' ends and alternative promoter usage. Although it originally came into the spotlight due to the potential of several of these isoforms to mimic p53 functions, it is now clear that...

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PMID: 34650986
DOI: 10.3389/fcell.2021.737735

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