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Article

SMAD3 deficiency promotes inflammatory aortic aneurysms in angiotensin II-infused mice via activation of iNOS.

Journal of the American Heart Association - 19 Jun 2013

Tan Chek K, Tan Eddie H, Luo Baiwen, Huang Charlotte L, Loo Joachim S, Choong Cleo, Tan Nguan S

Abstract excerpt

BACKGROUND: Ninety percent of the patients carrying distinct SMAD3 mutations develop aortic aneurysms and dissections, called aneurysms-osteoarthritis syndrome (AOS). However, the etiology and molecular events downstream of SMAD3 leading to the pathogenesis of aortic aneurysms in these patients still remain elusive. Therefore, we aimed to investigate the vascular phenotypes of SMAD3-knockout mice. METHODS AND...

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Source

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Identifiers

PMID: 23782924
DOI: 10.1161/JAHA.113.000269
PMCID: PMC3698794

Genes

SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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