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Article

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

10 Sept 2017

Abstract excerpt

The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete extracellular matrix proteins. Canonical TGF-β signaling mobilizes Smad2 and Smad3 transcription factors that control fibrosis by promoting gene expression. However, the importance of TGF-β-Smad2/3 signaling in...

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PMID: 28891814
DOI: 10.1172/jci94753

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