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Article

Replacing C189 in the bZIP domain of Zta with S, T, V, or A changes DNA binding specificity to four types of double-stranded DNA.

Biochemical and biophysical research communications - 2 Jul 2018

Ray Sreejana, Tillo Desiree, Assad Nima, Ufot Aniekanabasi, Deppmann Christopher, Durell Stewart R, Porollo Aleksey, Vinson Charles

Abstract excerpt

Zta is a bZIP transcription factor (TF) in the Epstein-Barr virus that binds unmethylated and methylated DNA sequences. Substitution of cysteine 189 of Zta to serine (Zta(C189S)) results in a virus that is unable to execute the lytic cycle, which was attributed to a change in binding to methylated DNA sequences. To learn more about the role of this position in defining sequence-specific DNA binding, we mutated...

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Share to 5-Methylcytosine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29772230
DOI: 10.1016/j.bbrc.2018.05.080
PMCID: PMC6417095

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EBP

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