Epstein–Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression

doi:10.1093/nar/gkv212

Article

Epstein–Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression

16 Mar 2015

Abstract excerpt

Lytic replication of the human gamma herpes virus Epstein-Barr virus (EBV) is an essential prerequisite for the spread of the virus. Differential regulation of a limited number of cellular genes has been reported in B-cells during the viral lytic replication cycle. We asked whether a viral bZIP transcription factor, Zta (BZLF1, ZEBRA, EB1), drives some of these changes. Using genome-wide chromatin...

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