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Article

Latency of Epstein-Barr virus is disrupted by gain-of-function mutant cellular AP-1 proteins that preferentially bind methylated DNA.

Proceedings of the National Academy of Sciences of the United States of America - 14 May 2013

Yu Kuan-Ping, Heston Lee, Park Richard, Ding Zhaowei, Wang'ondu Ruth, Delecluse Henri-Jacques, Miller George

Abstract excerpt

ZEBReplication Activator (ZEBRA), a viral basic zipper protein that initiates the Epstein-Barr viral lytic cycle, binds to DNA and activates transcription through heptamer ZEBRA response elements (ZREs) related to AP-1 sites. A component of the biologic action of ZEBRA is attributable to binding...

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Identifiers

PMID: 23625009
DOI: 10.1073/pnas.1301577110
PMCID: PMC3657822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23625009-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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