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Latency of Epstein-Barr virus is disrupted by gain-of-function mutant cellular AP-1 proteins that preferentially bind methylated DNA.

Proceedings of the National Academy of Sciences of the United States of America - 14 May 2013

Yu Kuan-Ping, Heston Lee, Park Richard, Ding Zhaowei, Wang'ondu Ruth, Delecluse Henri-Jacques, Miller George

Abstract excerpt

ZEBReplication Activator (ZEBRA), a viral basic zipper protein that initiates the Epstein-Barr viral lytic cycle, binds to DNA and activates transcription through heptamer ZEBRA response elements (ZREs) related to AP-1 sites. A component of the biologic action of ZEBRA is attributable to binding methylated CpGs in ZREs present in the promoters of viral lytic cycle genes. Residue S186 of ZEBRA, Z(S186), which is...

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PMID: 23625009
DOI: 10.1073/pnas.1301577110
PMCID: PMC3657822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Latency of Epstein-Barr virus is disrupted by gain-of-function mutant cellular AP-1 proteins that preferentially bind methylated DNA.PMID 23625009Read ↗

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