CpG-Methylation Regulates a Class of Epstein-Barr Virus Promoters

doi:10.1371/journal.ppat.1001114

Article

CpG-Methylation Regulates a Class of Epstein-Barr Virus Promoters

23 Sept 2010

Abstract excerpt

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian gene regulation. In general, cytosine-phosphatidyl-guanosine (CpG)-methylated promoters are transcriptionally repressed and nuclear proteins such as MECP2, MBD1, MBD2, and MBD4 bind CpG-methylated DNA and contribute to epigenetic silencing. Methylation of viral DNA also regulates gene expression of...

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