Article

ZBTB38 requires an extended N-terminal zinc finger network to read mCpG- and discriminate TpG-containing DNA sequences

2026-05-07

Abstract excerpt

Methylation of cytosine bases in the CpG context (mCpG) is an essential regulatory mechanism cells use to spatially and temporally orchestrate access to genomic regions and mediate transcription. In many diseases, DNA methylation patterns become inappropriately distributed leading to aberrant transcriptional outcomes. Methyl-CpG binding proteins (MBPs) are key epigenetic mediators that selectively recognize mCpG s...

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Literature Corpus work: 441ce9a1-a39f-5027-a1ea-f647cb73a881
DOI: 10.64898/2026.05.04.722763

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