Article
On the testing of Hardy-Weinberg proportions and equality of allele frequencies in males and females at biallelic genetic markers.
Genetic epidemiology - 1 Feb 2018
Graffelman Jan, Weir Bruce S
Abstract excerpt
Standard statistical tests for equality of allele frequencies in males and females and tests for Hardy-Weinberg equilibrium are tightly linked by their assumptions. Tests for equality of allele frequencies assume Hardy-Weinberg equilibrium, whereas the usual chi-square or exact test for Hardy-Weinberg equilibrium assume equality of allele frequencies in the sexes. In this paper, we propose ways to break this...
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