A note on exact tests of Hardy-Weinberg equilibrium.

doi:10.1086/429864

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Article

A note on exact tests of Hardy-Weinberg equilibrium.

American journal of human genetics - 1 May 2005

Wigginton Janis E, Cutler David J, Abecasis Goncalo R

Abstract excerpt

Deviations from Hardy-Weinberg equilibrium (HWE) can indicate inbreeding, population stratification, and even problems in genotyping. In samples of affected individuals, these deviations can also provide evidence for association. Tests of HWE are commonly performed using a simple chi2 goodness-of-fit test. We show that this chi2 test can have inflated type I error rates, even in relatively large samples (e.g.,...

Topics

Genetics, Population
Genotype
Humans
Models, Genetic
Statistics as Topic

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PMID: 15789306
DOI: 10.1086/429864
PMCID: PMC1199378

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