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Article

Adapting the logical basis of tests for Hardy-Weinberg Equilibrium to the real needs of association studies in human and medical genetics.

Genetic epidemiology - 1 Nov 2009

Goddard Katrina A B, Ziegler Andreas, Wellek Stefan

Abstract excerpt

The standard procedure to assess genetic equilibrium is a chi(2) test of goodness-of-fit. As is the case with any statistical procedure of that type, the null hypothesis is that the distribution underlying the data is in agreement with the model. Thus, a significant result indicates incompatibility of the observed data with the model, which is clearly at variance with the aim in the majority of applications: to...

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PMID: 19235187
DOI: 10.1002/gepi.20409

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