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Article

A heterozygote-homozygote test of Hardy-Weinberg equilibrium.

European journal of human genetics : EJHG - 1 Nov 2009

Zhou Jin J, Lange Kenneth, Papp Jeanette C, Sinsheimer Janet S

Abstract excerpt

The century-old Hardy-Weinberg law remains fundamental to population genetics. Typically Hardy-Weinberg equilibrium is tested in unrelated individuals using a chi(2) goodness-of-fit test that compares expected and observed numbers of heterozygotes and homozygotes. In this report, we propose a likelihood ratio test for Hardy-Weinberg equilibrium that accommodates a mixture of pedigree and random sample data. The...

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Identifiers

PMID: 19367317
DOI: 10.1038/ejhg.2009.57
PMCID: PMC2986695

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