Article
SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes.
Journal of the American Heart Association - 7 Dec 2021
Zhang Yongneng, Zervopoulos Sotirios D, Boukouris Aristeidis E, Lorenzana-Carrillo Maria Areli, Saleme Bruno, Webster Linda, Liu Yongsheng, Haromy Alois, Tabatabaei Dakhili Seyed Amirhossein, Ussher John R, Sutendra Gopinath, Michelakis Evangelos D
Abstract excerpt
Background Isolated loss-of-function single nucleotide polymorphisms (SNPs) for SIRT3 (a mitochondrial deacetylase) and UCP2 (an atypical uncoupling protein enabling mitochondrial calcium entry) have been associated with both pulmonary arterial hypertension (PAH) and insulin resistance, but their collective role in animal models and patients is unknown. Methods and Results In a prospective cohort of patients with...
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