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Combined analysis of single-cell and bulk transcriptome sequencing data identifies critical glycolysis genes in idiopathic pulmonary arterial hypertension

26 Mar 2025

Abstract excerpt

BACKGROUND: Abnormal glycolytic metabolism plays a significant role in pulmonary vascular remodeling in idiopathic pulmonary arterial hypertension (IPAH), yet the specific mechanisms remain unclear. The primary objective of this study is to investigate the key regulatory mechanisms of glycolysis in IPAH. METHODS: Bulk and single-cell sequencing data obtained from IPAH patient tissue samples were downloaded from...

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PMID: 40140873
DOI: 10.1186/s12967-025-06373-x

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