Article

Metabolic Profile in Endothelial Cells of Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Arterial Hypertension.

2021-11-08

Abstract excerpt

<title>Abstract</title> <p>Background Chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH) are two forms of pulmonary hypertension (PH) characterized by obstructive vasculopathy. Endothelial dysfunction along with metabolic changes towards increased glycolysis are important in PAH pathophysiology. Less is known about such abnormalities in endothelial cells (ECs) from CT...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eabeba0e-b49e-5226-9395-3b70e230a3ec
DOI: 10.21203/rs.3.rs-1008061/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic Profile in Endothelial Cells of Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Arterial Hypertension.DOI 10.21203/rs.3.rs-1008061/v1Read

Interrogation of the glycolytic axis in pulmonary arterial hypertension models and how modifying these can lead to potential therapeutic optionsSemantic proximity Read

Mitochondrial dysfunction drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigationSemantic proximity Read

Derivation and Characterisation of Endothelial Cells from Patients with Chronic Thromboembolic Pulmonary Hypertension.Semantic proximity Read

Lessons from Cancer Metabolism for Pulmonary Arterial Hypertension and FibrosisSemantic proximity Read

Metabolic Deregulation in Pulmonary HypertensionSemantic proximity Read

Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cellsSemantic proximity Read

Identification of key fatty acid metabolism-related genes in pulmonary arterial hypertension through bioinformatics analysis and experimental studiesSemantic proximity Read

Rewriting the Vascular Script: Epigenetic Modifiers as Scribes of Metabolic Reprogramming in Pulmonary HypertensionSemantic proximity Read

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.Semantic proximity Read

Combined analysis of single-cell and bulk transcriptome sequencing data identifies critical glycolysis genes in idiopathic pulmonary arterial hypertensionSemantic proximity Read

Identification of Hypoxia Induced Metabolism Associated Genes in Pulmonary HypertensionSemantic proximity Read

Metabolic phenotype analysis in patients with pulmonary hypertensionSemantic proximity Read