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Article

Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension.

Journal of molecular medicine (Berlin, Germany) - 1 Aug 2011

Sutendra Gopinath, Dromparis Peter, Bonnet Sébastien, Haromy Alois, McMurtry Michael S, Bleackley R Chris, Michelakis Evangelos D

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by enhanced proliferation and suppressed apoptosis of pulmonary artery smooth muscle cells (PASMC). This apoptosis resistance is characterized by PASMC mitochondrial hyperpolarization [in part, due to decreased pyruvate dehydrogenase (PDH) activity], decreased mitochondrial reactive oxygen species (mROS), downregulation of Kv1.5,...

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Source

Identifiers

PMID: 21809123
DOI: 10.1007/s00109-011-0762-2

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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