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Article

Variability of the drug response to nonsteroidal anti-inflammatory drugs according to cyclooxygenase-2 genetic polymorphism.

Drug design, development and therapy - 1 Jan 2017

Lee Sook Joung, Park Min Kyu, Shin Dong-Seong, Chun Min Ho

Abstract excerpt

PURPOSE: Cyclooxygenase (COX) is the main pharmacodynamic target of nonsteroidal anti-inflammatory drugs (NSAIDs). We investigated the inhibitory effects on COX-2 after NSAIDs administration using a lipopolysaccharide (LPS)-derived COX-2 induction model in whole blood, according to the genotypes of COX-2 single-nucleotide polymorphisms (SNPs). PATIENTS AND METHODS: Seven genotypes of COX-2 SNPs were selected from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29066864
DOI: 10.2147/DDDT.S143807
PMCID: PMC5604555

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