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Article

Influence of genetic polymorphisms on the pharmacokinetics of celecoxib and its two main metabolites in healthy Chinese subjects.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 15 Nov 2015

Liu Ruijuan, Gong Chuting, Tao Lei, Yang Wen, Zheng Xiaohong, Ma Pengcheng, Ding Li

Abstract excerpt

Celecoxib is a selective cyclooxygenase-2 inhibitor used extensively for the treatment of rheumatism and osteoarthritis. The aim of this study was to evaluate the influence of the genetic polymorphisms of CYP2C9, CYP2D6 and CYP3A4 on the pharmacokinetics (PK) of celecoxib and its two main metabolites, hydroxyl-celecoxib and carboxy-celecoxib, in healthy Chinese subjects, based on a bioequivalence study of...

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Identifiers

PMID: 26360837
DOI: 10.1016/j.ejps.2015.09.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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