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Article

Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs.

The American journal of cardiology - 15 Jun 2010

St Germaine Christine G, Bogaty Peter, Boyer Luce, Hanley James, Engert James C, Brophy James M

Abstract excerpt

The cardiovascular safety of cyclooxygenase-2-selective (coxibs) and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) is of concern, although most users remain free of adverse outcomes. A gene-drug interaction could modulate this cardiovascular risk through prostaglandin synthesis or inflammatory pathways. From an existing acute coronary syndrome cohort (Recurrence and Inflammation in the Acute Coronary...

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Source

Identifiers

PMID: 20538124
DOI: 10.1016/j.amjcard.2010.01.352

Genes

CRP
PTGS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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