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Paracetamol and Pain Modulation by TRPV1, UGT2B15, SULT1A1 Genotypes: A Randomized Clinical Trial in Healthy Volunteers

1 Mar 2019

Abstract excerpt

BACKGROUND: The influence of the genetic polymorphism of enzymes and receptors involved in paracetamol metabolism and mechanism of action has not been investigated. This trial in healthy volunteers investigated the link between paracetamol pain relief and the genetic polymorphism of 23 enzymes and receptors. DESIGN: This randomized double-blind crossover controlled pilot study took place in the Clinical...

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PMID: 30908574
DOI: 10.1093/pm/pnz037

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