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Article

The cyclooxygenase 2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production.

Clinical pharmacology and therapeutics - 1 Dec 2006

Skarke Carsten, Reus Maximilian, Schmidt Ronald, Grundei Inga, Schuss Patrick, Geisslinger Gerd, Lötsch Jörn

Abstract excerpt

OBJECTIVE: Our objective was to assess the role of the reportedly functional PTGS2 (prostaglandin-endoperoxide synthase 2/cyclooxygenase [COX] 2) promoter mutation -765G>C for the COX-2-inhibiting effects of celecoxib. METHODS: Twenty healthy carriers of the -765GG genotype and -765CC genotype (n = 10 each) received 200 mg of celecoxib orally. Blood samples were drawn at baseline and at 1, 3, 6, 9, and 24 hours...

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Identifiers

PMID: 17178263
DOI: 10.1016/j.clpt.2006.08.021

Genes

PTGS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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