Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The cyclooxygenase 2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production.

Clinical pharmacology and therapeutics - 1 Dec 2006

Skarke Carsten, Reus Maximilian, Schmidt Ronald, Grundei Inga, Schuss Patrick, Geisslinger Gerd, Lötsch Jörn

Abstract excerpt

OBJECTIVE: Our objective was to assess the role of the reportedly functional PTGS2 (prostaglandin-endoperoxide synthase 2/cyclooxygenase [COX] 2) promoter mutation -765G>C for the COX-2-inhibiting effects of celecoxib. METHODS: Twenty healthy carriers of the -765GG genotype and -765CC genotype (n...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclooxygenase 2
Share to Cyclooxygenase Inhibitors
Share to Dinoprostone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Lipopolysaccharides

Share to Pharmacogenetics

Share to Pyrazoles

Share to Sulfonamides

Source

Identifiers

PMID: 17178263
DOI: 10.1016/j.clpt.2006.08.021

Genes

PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17178263-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The cyclooxygenase 2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production.PMID 17178263Read ↗

Variability of the drug response to nonsteroidal anti-inflammatory drugs according to cyclooxygenase-2 genetic polymorphism.Semantic proximity Read ↗

Pharmacogenomics of cyclooxygenases.Semantic proximity Read ↗

A common single-nucleotide polymorphism in cyclooxygenase-2 disrupts microRNA-mediated regulation.Semantic proximity Read ↗

Functional effects and gender association of COX-2 gene polymorphism G-765C in bronchial asthma.Semantic proximity Read ↗

The prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/ COX2) rs5277 polymorphism does not influence risk of colorectal cancer in an Iranian population.Semantic proximity Read ↗

Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs.Semantic proximity Read ↗

Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.Semantic proximity Read ↗

Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).Semantic proximity Read ↗

A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control studySemantic proximity Read ↗

Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response.Semantic proximity Read ↗

Common polymorphisms of cyclooxygenase-2 and prostaglandin E2 receptor and increased risk for acute coronary syndrome in coronary artery disease.Semantic proximity Read ↗

Cyclooxygenase 1(COX1) polymorphisms in African-American and caucasian populationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.