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Article

Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs.

Clinical pharmacology and therapeutics - 1 May 2006

Lee Yun-Sil, Kim Hyungsuk, Wu Tian-Xia, Wang Xiao-Min, Dionne Raymond A

Abstract excerpt

BACKGROUND: Wide interindividual variation in responses to cyclooxygenase (COX) inhibitory drugs limits their clinical utility and safety. METHODS: To better understand the molecular responses to COX inhibition, we analyzed the gene expression level of the genes encoding enzymes related to prostaglandin production including the COX-1 gene (PTGS1) and the COX-2 gene (PTGS2), as well as their genetic polymorphisms,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16678543
DOI: 10.1016/j.clpt.2006.01.013

Genes

PTGS2
PTGS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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