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Article

Platelet responsiveness to in vitro aspirin is independent of COX-1 and COX-2 protein levels and polymorphisms.

Thrombosis research - 1 Jan 2008

Takahashi Shinichi, Ushida Miho, Komine Risa, Shimodaira Aya, Uchida Toshihiro, Ishihara Hiroaki, Shibano Toshiro, Watanabe Gentaro, Ikeda Yasuo, Murata Mitsuru

Abstract excerpt

Aspirin's inhibitory effect on platelet function has been shown to be highly heterogeneous. However, due to the considerable individual variation in pharmacokinetics after aspirin intake, it has been difficult to investigate the mechanism of aspirin resistance empirically. Our objective was to examine whether platelet responsiveness to in vitro aspirin treatment could be affected by cyclooxygenase (COX)-1/2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17631383
DOI: 10.1016/j.thromres.2007.05.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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