Article
Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity.
The Biochemical journal - 15 Nov 2006
Lamanna William C, Baldwin Rebecca J, Padva Michael, Kalus Ina, Ten Dam Gerdy, van Kuppevelt Toin H, Gallagher John T, von Figura Kurt, Dierks Thomas, Merry Catherine L R
Abstract excerpt
HS (heparan sulfate) is essential for normal embryonic development. This requirement is due to the obligatory role for HS in the signalling pathways of many growth factors and morphogens that bind to sulfated domains in the HS polymer chain. The sulfation patterning of HS is determined by a complex interplay of Golgi-located N- and O-sulfotransferases which sulfate the heparan precursor and cell surface...
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