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Article

Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Feb 2011

Conway Christopher D, Howe Kathy M, Nettleton Nicole K, Price David J, Mason John O, Pratt Thomas

Abstract excerpt

Heparan sulfate proteoglycans are cell surface and secretory proteins that modulate intercellular signaling pathways including Slit/Robo and FGF/FGFR. The heparan sulfate sugar moieties on HSPGs are subject to extensive postsynthetic modification, generating enormous molecular complexity that has been postulated to provide increased diversity in the ability of individual cells to respond to specific signaling...

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Identifiers

PMID: 21307234
DOI: 10.1523/JNEUROSCI.2579-10.2011
PMCID: PMC6633041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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