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Article

Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche

20 Sept 2010

Abstract excerpt

Glial cell line-derived neurotrophic factor (GDNF) is a heparan sulfate (HS)-binding factor. GDNF is produced by somatic Sertoli cells, where it signals to maintain spermatogonial stem cells (SSCs) and reproduction. Here, we investigate the roles of extracellular HS 6-O-endosulfatases (Sulfs), Sulf1 and Sulf2, in the matrix transmission of GDNF from Sertoli cells to SSCs. Although Sulfs are not required for...

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PMID: 20855470
DOI: 10.1093/glycob/cwq133

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