Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Roles of heparan sulfate sulfation in dentinogenesis.

The Journal of biological chemistry - 6 Apr 2012

Hayano Satoru, Kurosaka Hiroshi, Yanagita Takeshi, Kalus Ina, Milz Fabian, Ishihara Yoshihito, Islam Md Nurul, Kawanabe Noriaki, Saito Masahiro, Kamioka Hiroshi, Adachi Taiji, Dierks Thomas, Yamashiro Takashi

Abstract excerpt

Cell surface heparan sulfate (HS) is an essential regulator of cell signaling and development. HS traps signaling molecules, like Wnt in the glycosaminoglycan side chains of HS proteoglycans (HSPGs), and regulates their functions. Endosulfatases Sulf1 and Sulf2 are secreted at the cell surface to selectively remove 6-O-sulfate groups from HSPGs, thereby modifying the affinity of cell surface HSPGs for its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dentin
Share to Heparan Sulfate Proteoglycans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heparitin Sulfate

Share to Sialoglycoproteins

Share to Sulfatases

Share to Sulfotransferases

Share to Tooth Abnormalities

Source

Open in PubMed Open full text

Identifiers

PMID: 22351753
DOI: 10.1074/jbc.M111.332924
PMCID: PMC3320973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles of heparan sulfate sulfation in dentinogenesis.PMID 22351753Read ↗

Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development.Semantic proximity Read ↗

Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.Semantic proximity Read ↗

Drosophila heparan sulfate 6-O-endosulfatase Sulf1 facilitates wingless (Wg) protein degradation.Semantic proximity Read ↗

QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling.Semantic proximity Read ↗

Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation.Semantic proximity Read ↗

Skeletal Dysplasias Caused by Sulfation Defects.Semantic proximity Read ↗

Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis.Semantic proximity Read ↗

Sulfation of Glycosaminoglycans and Its Implications in Human Health and Disorders.Semantic proximity Read ↗

Heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, regulate glomerular integrity by modulating growth factor signaling.Semantic proximity Read ↗

SLC26A2-mediated sulfate metabolism is essential for the tooth developmentSemantic proximity Read ↗

Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity.Semantic proximity Read ↗

Human genetic disorders and knockout mice deficient in glycosaminoglycan.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.