Article
Human plasmacytoid dendritic cells acquire phagocytic capacity by TLR9 ligation in the presence of soluble factors produced by renal epithelial cells.
Kidney international - 1 Feb 2018
Ruben Jurjen M, García-Romo Gina Stella, Breman Eytan, van der Kooij Sandra, Redeker Anke, Arens Ramon, van Kooten Cees
Abstract excerpt
Plasmacytoid dendritic cells (pDCs) are antigen presenting cells specialized in viral recognition through Toll-like receptor (TLR)7 and TLR9, and produce vast amounts of interferon alpha upon ligation of these TLRs. We had previously demonstrated a strong influx of pDCs in the tubulointerstitium of renal biopsies at the time of acute rejection. However, the role of human pDCs in mediating acute or chronic...
Topics
- Antigen Presentation
- Apoptosis
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Line
- Coculture Techniques
- Cytomegalovirus
- Dendritic Cells
- Epithelial Cells
- Graft Rejection
- Granulocyte-Macrophage Colony-Stimulating Factor
- Host-Pathogen Interactions