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Article

Distinctive role of efferocytosis in dendritic cell maturation and migration in sterile or infectious conditions.

Immunology - 1 Jul 2017

Penteado Letícia de Aquino, Dejani Naiara Naiana, Verdan Felipe Fortino, Orlando Allan Botinhon, Niño Victoria Eugenia, Dias Fernanda De Nuzzi, Salina Ana Carolina Guerta, Medeiros Alexandra Ivo

Abstract excerpt

Efferocytosis, or clearance of apoptotic cells (ACs), by dendritic cells (DCs) leads to immune response suppression and tolerance to self-antigens. However, efferocytosis of infected apoptotic cells (IACs) leads to the production of a mixed pro- and anti-inflammatory cytokine milieu. We examined the DC phenotype and ability to migrate after phagocytosis of ACs or IACs and observed higher levels of CD86 and CCR7...

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Source

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Identifiers

PMID: 28267881
DOI: 10.1111/imm.12731
PMCID: PMC5461093

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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