Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2009

Matsui Toshimichi, Connolly John E, Michnevitz Mark, Chaussabel Damien, Yu Chun-I, Glaser Casey, Tindle Sasha, Pypaert Marc, Freitas Heidi, Piqueras Bernard, Banchereau Jacques, Palucka A Karolina

Abstract excerpt

Plasmacytoid dendritic cells (pDCs) are key regulators of antiviral immunity. They rapidly secrete IFN-alpha and cross-present viral Ags, thereby launching adaptive immunity. In this study, we show that activated human pDCs inhibit replication of cancer cells and kill them in a contact-dependent fashion. Expression of CD2 distinguishes two pDC subsets with distinct phenotype and function. Both subsets secrete...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B7-1 Antigen
Share to CD2 Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Cytotoxicity, Immunologic

Share to Dendritic Cells

Share to Interleukin-12 Subunit p40

Share to Neoplasms

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 19454677
DOI: 10.4049/jimmunol.0802008
PMCID: PMC2749454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions.PMID 19454677Read ↗

Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses.Semantic proximity Read ↗

Human dendritic cell subsets: an update.Semantic proximity Read ↗

Human Blood CD1c+ Dendritic Cells Encompass CD5high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions.Semantic proximity Read ↗

Plasmacytoids dendritic cells are a therapeutic target in anticancer immunity.Semantic proximity Read ↗

SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4Semantic proximity Read ↗

Tumoricidal activity of human dendritic cells.Semantic proximity Read ↗

Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T cells despite lower Ag uptake than myeloid dendritic cell subsetsSemantic proximity Read ↗

Phenotypic and functional differences of dendritic cells in tumor.Semantic proximity Read ↗

Activation and selective IL-17 response of human Vγ9Vδ2 T lymphocytes by TLR-activated plasmacytoid dendritic cells.Semantic proximity Read ↗

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.Semantic proximity Read ↗

Opposing Roles of Dectin-1 Expressed on Human Plasmacytoid Dendritic Cells and Myeloid Dendritic Cells in Th2 PolarizationSemantic proximity Read ↗

Phenotypes and Functions of Human Dendritic Cell Subsets in the Tumor Microenvironment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.