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Article

Controllable release of interleukin-4 in double-layer sol-gel coatings on TiO2 nanotubes for modulating macrophage polarization.

Biomedical materials (Bristol, England) - 18 Apr 2018

Li Mengting, Gao Lili, Chen Junhong, Zhang Yan, Wang Jianxin, Lu Xiong, Duan Ke, Weng Jie, Feng Bo

Abstract excerpt

Classically activated M1 macrophages and alternatively activated M2 macrophages play key roles in regulating immune responses. M1 macrophages initiate angiogenesis in the early stages of wound healing or after implantation. However, their prolonged activation can lead to chronic inflammation. We speculated that biomedical implants with specific properties can induce a shift from M1 to M2 macrophages at a specific...

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Identifiers

PMID: 29056612
DOI: 10.1088/1748-605X/aa9526

Genes

IL4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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