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Article

Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype.

Biotechnology and bioengineering - 1 Jun 2014

Boehler R M, Kuo R, Shin S, Goodman A G, Pilecki M A, Gower R M, Leonard J N, Shea L D

Abstract excerpt

Gene delivery from biomaterials can create an environment that promotes and guides tissue formation. However, the immune response induced upon biomaterial implantation can be detrimental to tissue regeneration. Macrophages play a central role in mediating early phases of this response, and functional "polarization" of macrophages towards M1 (inflammatory) or M2 (anti-inflammatory) phenotypes may bias the local...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24375008
DOI: 10.1002/bit.25175
PMCID: PMC4232188

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TNF

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