Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates.

Abstract excerpt

Peptide macrocycles are promising therapeutic molecules because they are protease resistant, structurally rigid, membrane permeable, and capable of modulating protein-protein interactions. Here, we report the characterization of the dual function macrocyclase-peptidase enzyme involved in the biosynthesis of the highly toxic amanitin toxin family of macrocycles. The enzyme first removes 10 residues from the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Basidiomycota
• Share to Cyclization
• Share to Kinetics