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Article

Sequence determinants governing the topology and biological activity of a lasso peptide, microcin J25.

Chembiochem : a European journal of chemical biology - 13 Feb 2012

Ducasse Rémi, Yan Kok-Phen, Goulard Christophe, Blond Alain, Li Yanyan, Lescop Ewen, Guittet Eric, Rebuffat Sylvie, Zirah Séverine

Abstract excerpt

Microcin J25 is a potent antibacterial peptide produced by Escherichia coli AY25. It displays a lasso structure, which consists of a knot involving an N-terminal macrolactam ring through which the C-terminal tail is threaded and sterically trapped. In this study, we rationally designed and performed site-specific mutations in order to pinpoint the sequence determinants of the lasso topology. Structures of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22287061
DOI: 10.1002/cbic.201100702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sequence determinants governing the topology and biological activity of a lasso peptide, microcin J25.PMID 22287061Read ↗

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