Chimeric peptidomimetic antibiotics against Gram-negative bacteria.

doi:10.1038/s41586-019-1665-6

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Article

Chimeric peptidomimetic antibiotics against Gram-negative bacteria.

Nature - 1 Dec 2019

Luther Anatol, Urfer Matthias, Zahn Michael, Müller Maik, Wang Shuang-Yan, Mondal Milon, Vitale Alessandra, Hartmann Jean-Baptiste, Sharpe Timothy, Monte Fabio Lo, Kocherla Harsha, Cline Elizabeth, Pessi Gabriella, Rath Parthasarathi, Modaresi Seyed Majed, Chiquet Petra, Stiegeler Sarah, Verbree Carolin, Remus Tobias, Schmitt Michel, Kolopp Caroline, Westwood Marie-Anne, Desjonquères Nicolas, Brabet Emile, Hell Sophie, LePoupon Karen, Vermeulen Annie, Jaisson Régis, Rithié Virginie, Upert Grégory, Lederer Alexander, Zbinden Peter, Wach Achim, Moehle Kerstin, Zerbe Katja, Locher Hans H, Bernardini Francesca, Dale Glenn E, Eberl Leo, Wollscheid Bernd, Hiller Sebastian, Robinson John A, Obrecht Daniel

Abstract excerpt

There is an urgent need for new antibiotics against Gram-negative pathogens that are resistant to carbapenem and third-generation cephalosporins, against which antibiotics of last resort have lost most of their efficacy. Here we describe a class of synthetic antibiotics inspired by scaffolds derived from natural products. These chimeric antibiotics contain a β-hairpin peptide macrocycle linked to the macrocycle...

Topics

Animals
Anti-Bacterial Agents
Bacterial Outer Membrane Proteins
Biological Products
Drug Discovery
Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Escherichia coli Proteins

Fluorescence

Gram-Negative Bacteria

Humans

Lipopolysaccharides

Macrocyclic Compounds

Male

Mice

Microbial Sensitivity Tests

Microbial Viability

Microscopy, Electron, Transmission

Models, Molecular

Source

Open in PubMed

Identifiers

PMID: 31645764
DOI: 10.1038/s41586-019-1665-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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