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Article

Substrate Plasticity of a Fungal Peptide α-N-Methyltransferase.

ACS chemical biology - 17 Jul 2020

Song Haigang, Fahrig-Kamarauskaitè Ju Ratè, Matabaro Emmanuel, Kaspar Hannelore, Shirran Sally L, Zach Christina, Pace Amy, Stefanov Bozhidar-Adrian, Naismith James H, Künzler Markus

Abstract excerpt

The methylation of amide nitrogen atoms can improve the stability, oral availability, and cell permeability of peptide therapeutics. Chemical N-methylation of peptides is challenging. Omphalotin A is a ribosomally synthesized, macrocylic dodecapeptide with nine backbone N-methylations. The fungal natural product is derived from the precursor protein, OphMA, harboring both the core peptide and a SAM-dependent...

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Identifiers

PMID: 32491837
DOI: 10.1021/acschembio.0c00237
PMCID: PMC7372559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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