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Article

Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase.

Biochemistry - 31 Jan 2017

Galea Charles A, Roberts Kade D, Zhu Yan, Thompson Philip E, Li Jian, Velkov Tony

Abstract excerpt

Polymyxins remain one of the few antibiotics available for treating antibiotic resistant bacteria. Here we describe polymyxin B thioesterase which performs the final step in polymyxin B biosynthesis. Isolated thioesterase catalyzed cyclization of an N-acetylcystamine polymyxin B analogue to form polymyxin B. The thioesterase contained a catalytic cysteine unlike most thioesterases which possess a serine....

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Identifiers

PMID: 28071053
DOI: 10.1021/acs.biochem.6b01139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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