Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insights into the biosynthesis and stability of the lasso peptide capistruin.

Chemistry & biology - 24 Dec 2009

Knappe Thomas A, Linne Uwe, Robbel Lars, Marahiel Mohamed A

Abstract excerpt

Capistruin is a 19-residue ribosomally synthesized lasso peptide encoded by the capABCD gene cluster in Burkholderia thailandensis. It is composed of an N-terminal 9-residue macrolactam ring, through which the 10-residue C-terminal tail is threaded. Using a heterologous capistruin production system in Escherichia coli, we have generated 48 mutants of the precursor protein CapA to gain insights into capistruin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Burkholderia
Share to Multigene Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptides

Share to Protein Engineering

Share to Protein Stability

Share to Recombinant Proteins

Share to Temperature

Source

Identifiers

PMID: 20064439
DOI: 10.1016/j.chembiol.2009.11.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insights into the biosynthesis and stability of the lasso peptide capistruin.PMID 20064439Read ↗

Sequence diversity in the lasso peptide framework: discovery of functional microcin J25 variants with multiple amino acid substitutions.Semantic proximity Read ↗

Sequence determinants governing the topology and biological activity of a lasso peptide, microcin J25.Semantic proximity Read ↗

Heterologous Production of Lasso Peptide Capistruin in a Burkholderia HostSemantic proximity Read ↗

Investigation of the Biosynthesis of the Lasso Peptide Chaxapeptin Using an E. coli-Based Production System.Semantic proximity Read ↗

Systematic structure-activity analysis of microcin J25.Semantic proximity Read ↗

Cell-Free Biosynthesis to Evaluate Lasso Peptide Formation and Enzyme-Substrate ToleranceSemantic proximity Read ↗

How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.Semantic proximity Read ↗

A Broad Spectrum Lasso Peptide Antibiotic Targeting the Bacterial RibosomeSemantic proximity Read ↗

High-throughput engineering and modification of non-ribosomal peptide synthetases based on Golden Gate assemblySemantic proximity Read ↗

CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from Streptomyces canus.Semantic proximity Read ↗

Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates.Semantic proximity Read ↗

Plasticity of the Malleobactin Pathway and Its Impact on Siderophore Action in Human Pathogenic BacteriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.