Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peptide macrocyclization catalyzed by a prolyl oligopeptidase involved in α-amanitin biosynthesis.

Chemistry & biology - 18 Dec 2014

Luo Hong, Hong Sung-Yong, Sgambelluri R Michael, Angelos Evan, Li Xuan, Walton Jonathan D

Abstract excerpt

Amatoxins are ribosomally encoded and posttranslationally modified peptides that account for the majority of fatal mushroom poisonings of humans. A representative amatoxin is the bicyclic octapeptide α-amanitin, formed via head-to-tail macrocyclization, which is ribosomally biosynthesized as a 35...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Biocatalysis
Share to Cyclization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kinetics

Share to Molecular Sequence Data

Share to Mutation

Share to Serine Endopeptidases

Share to Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 25484237
DOI: 10.1016/j.chembiol.2014.10.015
PMCID: PMC4272623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25484237-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peptide macrocyclization catalyzed by a prolyl oligopeptidase involved in α-amanitin biosynthesis.PMID 25484237Read ↗

Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates.Semantic proximity Read ↗

Substrate Plasticity of a Fungal Peptide α-N-Methyltransferase.Semantic proximity Read ↗

Helper bacteria halt and disarm mushroom pathogens by linearizing structurally diverse cyclolipopeptidesSemantic proximity Read ↗

Insights into the biosynthesis and stability of the lasso peptide capistruin.Semantic proximity Read ↗

Escherichia coli peptidase A, B, or N can process translation inhibitor microcin C.Semantic proximity Read ↗

In vivo challenges of anti-diabetic peptide therapeutics: Gastrointestinal stability, toxicity and allergenicitySemantic proximity Read ↗

Inhibition of SARS-CoV-2 3CLpro <i>in vitro</i> by chemically modified tyrosinase from Agaricus bisporusSemantic proximity Read ↗

Generation, characterisation and identification of bioactive peptides from Mesopelagic fish protein hydrolysates using in silico and in vitro approaches.Semantic proximity Read ↗

Enzymatic Synthesis and Functional Characterization of Bioactive Microcin C-Like Compounds with Altered Peptide Sequence and Length.Semantic proximity Read ↗

Prodomain processing of recombinant plasmepsin II and IV, the aspartic proteases of Plasmodium falciparum, is auto- and trans-catalytic.Semantic proximity Read ↗

Concerted action of P450 plus helper protein to form the amino-hydroxy-piperidone moiety of the potent protease inhibitor crocapeptin.Semantic proximity Read ↗

Fatty acid hydrolysis of acyl marinobactin siderophores by Marinobacter acylases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.