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Article

Polycyclic Peptide Therapeutics

25 Jan 2013

Abstract excerpt

Owing to their excellent binding properties, high stability, and low off-target toxicity, polycyclic peptides are an attractive molecule format for the development of therapeutics. Currently, only a handful of polycyclic peptides are used in the clinic; examples include the antibiotic vancomycin, the anticancer drugs actinomycin D and romidepsin, and the analgesic agent ziconotide. All clinically used polycyclic...

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PMID: 23355488
DOI: 10.1002/cmdc.201200513

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