Parkinson’s disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss

Abstract excerpt

The complex and heterogeneous nature of Parkinson's disease (PD) is still not fully understood. However, increasing evidence supports mitochondrial impairment as a major driver of neurodegeneration. Miro1, a mitochondrial GTPase encoded by the RHOT1 gene, is involved in mitochondrial transport, mitophagy and mitochondrial calcium buffering, and is therefore essential for maintaining mitochondrial homeostasis....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Histone Deacetylase Inhibitors Research
• Share to Nuclear Receptors and Signaling
• Share to Parkinson's Disease Mechanisms and Treatments