Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations.

doi:10.1001/jamapsychiatry.2017.3016

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Article

Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations.

JAMA psychiatry - 1 Dec 2017

Milaneschi Yuri, Lamers Femke, Peyrot Wouter J, Baune Bernhard T, Breen Gerome, Dehghan Abbas, Forstner Andreas J, Grabe Hans J, Homuth Georg, Kan Carol, Lewis Cathryn, Mullins Niamh, Nauck Matthias, Pistis Giorgio, Preisig Martin, Rivera Margarita, Rietschel Marcella, Streit Fabian, Strohmaier Jana, Teumer Alexander, Van der Auwera Sandra, Wray Naomi R, Boomsma Dorret I, Penninx Brenda W J H

Abstract excerpt

Importance: The association between major depressive disorder (MDD) and obesity may stem from shared immunometabolic mechanisms particularly evident in MDD with atypical features, characterized by increased appetite and/or weight (A/W) during an active episode. Objective: To determine whether subgroups of patients with MDD stratified according to the A/W criterion had a different degree of genetic overlap with...

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PMID: 29049554
DOI: 10.1001/jamapsychiatry.2017.3016
PMCID: PMC6396812

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