Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of nicotine metabolism and sex with relapse following varenicline and nicotine replacement therapy.

Experimental and clinical psychopharmacology - 1 Oct 2017

Glatard Anaïs, Dobrinas Maria, Gholamrezaee Mehdi, Lubomirov Rubin, Cornuz Jacques, Csajka Chantal, Eap Chin B

Abstract excerpt

Nicotine is metabolized into cotinine and then into trans-3'-hydroxycotinine, mainly by cytochrome P450 2A6. Recent studies reported better effectiveness of varenicline in women and in nicotine normal metabolizers phenotypically determined by nicotine-metabolite ratio. Our objective was to study the influence of nicotine-metabolite ratio, CYP2A6 genotype and sex on the response to nicotine replacement therapy and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cotinine
Share to Cytochrome P-450 CYP2A6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Longitudinal Studies

Share to Nicotine

Share to Recurrence

Share to Smoking

Share to Smoking Cessation

Share to Tobacco Products

Source

Identifiers

PMID: 29048184
DOI: 10.1037/pha0000141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of nicotine metabolism and sex with relapse following varenicline and nicotine replacement therapy.PMID 29048184Read ↗

Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers.Semantic proximity Read ↗

Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction.Semantic proximity Read ↗

Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genesSemantic proximity Read ↗

Nicotine Dependence, Nicotine Metabolism, and the Extent of Compensation in Response to Reduced Nicotine Content Cigarettes.Semantic proximity Read ↗

Application of a pharmacokinetic/pharmacogenetic approach to assess the nicotine metabolic profile of smokers in the real-life setting.Semantic proximity Read ↗

Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies.Semantic proximity Read ↗

The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex.Semantic proximity Read ↗

Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption.Semantic proximity Read ↗

CYP2A6 Longitudinal Effects in Young Smokers.Semantic proximity Read ↗

Determinants of the rate of nicotine metabolism and effects on smoking behavior.Semantic proximity Read ↗

Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers.Semantic proximity Read ↗

Genetic variation in nicotine metabolism predicts the efficacy of extended-duration transdermal nicotine therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.